Sentence examples for have formally demonstrated from inspiring English sources

We have formally demonstrated this for AP-1 IPs (Figures 2&3, Tables 1&2).

Here we have formally demonstrated that when CTL-mediated killing occurs early during the intracellular eclipse phase it can control HIV replication very efficiently, while remaining consistent with current observations on the up-slopes and down-slopes of the viral load observed during CD8+ T cell depletion experiments and antiretroviral treatment.

Firstly, we have formally demonstrated the presence of the signalling complex described to mediate the rapid action of oestrogen in breast cancer within human breast tissues.

The PALETTE trial has formally demonstrated the benefit of treating patients with anti-angiogenic agent over placebo in terms of PFS in a Phase III setting (Table  2) [ 18, 19].

Rituximab is thus far the only agent that has formally demonstrated significant slowing of structural joint damage in RA patients with an inadequate response to or who are intolerant of TNF inhibitors [ 49].

While we observed viral nucleic acid sequences in the samples, we have not formally demonstrated that these viruses are replicating.

Although we have not formally demonstrated that zinc uptake is required for zinc to be toxic to bacteria, it is worth noting that bacterial death correlates with increased cytosolic free zinc in our experiments.

Although we have not formally demonstrated that this gate contains exclusively lymphocytes and given the recent observations of aberrant cell population in relapsed AML patients requiring careful flow cytometry evaluation, 23 prior studies have consistently demonstrated that this gate contains lymphocytes in patients with AML.

We have not formally demonstrated that CtpC is a zinc efflux pump in M. tuberculosis, but this appears to be the case, since (1) it is phylogenetically related to zinc P1B-type ATPases, (2) its expression is induced upon exposure of bacilli to zinc, (3) a ctpC null mutant of M. tuberculosis accumulates zinc in a specific and uncontrolled manner, and (4) this mutant is highly sensitive to zinc.

Several lines of evidence have linked these cohesion establishment factors to the DNA replication fork, though their specific requirement for cohesion establishment during S-phase, as opposed to cohesin loading onto chromosomes or maintaining sister chromatid cohesion, has formally been demonstrated only for the Ctf18 complex and Csm3 (Xu et al. 2007).

However, not all DNA repair systems are coupled to transcription, and to date NER (the pathway involved in the reparation of these lesions) is the only pathway for which transcription coupled repair has been formally demonstrated.