Sentence examples for have established roles from inspiring English sources

Although some peripheral clocks have established roles [1], it is unclear what local brain clocks do [2, 3].

IL-1α (and IL-1β to a lesser extent) induces the production of CXCL1 and CXCL2, chemokines that have established roles in neutrophilic chemotaxis via CXCR1 and CXCR250,51,52.

We use live-cell imaging to visualize, localize and quantify proteolysis as it occurs in real-time and thereby have established roles for lysosomal cysteine proteases both pericellularly and intracellularly in tumor proteolysis.

PREX1 promotes the motility and invasion of glioblastoma cells, promoting Rac-mediated activation of p21-associated kinases and atypical PKC, which have established roles in cell motility.

Roberto: For the most part, we have established roles when it comes to making music.

CXCR4 receptors have established roles in tumor metastasis [11].

Cholesterol also has established roles in gallbladder disease [ 21, 32] and modifies other gastrointestinal functions.

Dlk1 has established roles in influencing proliferation and differentiation of several tissues, including adipose [ 50, 72– 74] and skeletal muscle [ 55].

HIF has established roles in the response to hypoxia (Moniz et al., 2014; Semenza, 2011), and several studies using cell-specific HIF-α knockout have established a role for HIFs in the immune response.

Although CGRP has established roles in central nociceptive transmission and neurogenic inflammation in peripheral tissues (17, 18), its role in modulating peripheral nociception is poorly understood.

We next investigated the differentially expressed targets of miR-29 and miR-130 (File S4) that had established roles in adult CD8+ T cell function.