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Previous studies have documented alterations in intracellular trafficking and posttranslational processing of CD36 in the diabetic muscle (5, 39, 40).
Though recent reports have documented alterations of some oncogenes and tumor suppressor genes, the exact molecular and genetic basis of esophageal carcinogenesis still remains poorly understood [ 6].
Previous studies have documented alterations of the complement pathway in human hepatitis C; indeed, plasma C3 has been proposed as a marker for activity in this disease [ 24].
In addition, a number of studies have documented alterations in the HMT EZH2, which is responsible for the repressive H3K27me3 modification, in prostate cancer.
Disruption of the ALP is a common hallmark of lysosomal storage diseases and several have documented alterations in the nervous system, which may contribute in part to the onset and progression of nervous system pathophysiology [ 13].
Many reports in the pathology literature have documented alterations in the expression of desmosomal cadherins during tumourigenesis, and LOH in the region of the desmosomal cadherin gene cluster on chromosome 18 has been observed in oesophageal and head and neck cancer (reviewed by Chidgey, 2002).
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We have documented alteration in the levels of specific histone H2A modifications, as well as isoforms when the activation state of the AT1R changes.
Several investigators have documented alteration of minor gangliosides in human AD.
Patients who had had a history of malignancy other than OSCC or had documented alterations in renal function (urea >50 mg dl−1, creatinine >1.2 mg dl−1) were excluded.
In line with our observations, other studies have documented that alterations in APPL1 expression can differentially affect signaling depending on the stimulus.
Although several postmortem morphometric studies have documented developmental alterations in the neocortex [ 4, 5, 17- 19], cerebellum, and brainstem [ 20, 21], the reported morphometric characteristics of the developmental alterations in subcortical structures are limited to the amygdala [ 22] and hippocampus [ 23].
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