The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures.
In contrast to most naturally occurring protease inhibitors, which have diverse structures but converge to a similar inhibitory archetype, antibody inhibitors provide an opportunity to develop divergent mechanisms of inhibition from a single scaffold.
RNAs have diverse structures that include bulges and internal loops able to form tertiary contacts or serve as ligand binding sites.
Because paa genes show a patchy phylogenetic distribution and previously observed paa clusters have diverse structures that appear to be independent of the species phylogeny, we felt that this pathway was important to study from an evolutionary standpoint.
These include the provision of shade, the condition under which coffee grows best - but it 'must have diverse structure, with at least two strata present' and 'be diversified with at least 12 species of native trees'.
In species where only one cathelicidin is encoded, the mature peptide falls into the α-helical subgroup, however, in other animals, cathelicidins have diverse structure of the mature peptide.
The ToxCast data set also consists of compounds that have diverse structure, size, and chemical composition, albeit with similar functionality important for interactions with PXR [see Supplemental Material, Figure 1 (doi:10.1289/ehp.1001930)].
According to him, the Southern states suffered differently from colonialism and postcolonial relations, having diverse structures that cannot be fought by a single Universalist front.
These genes had diverse structures and were distributed on chromosome 1, 2, 4, 6, 7, 8, 11, 12, 13, 14, and 18. Phylogenetic analysis suggested that these BURP family genes could be classified into 5 subfamilies, and one of which defines a new subfamily, BURPV.
In conclusion, 30 hits (10 to each protein) having diverse structure and binding modes with all the three proteins active sites were selected as leading novel inhibitors.
Likewise, heparin has diverse, structure-related biological properties, only one of which is anti-coagulation and this can be manipulated through judicious structural modification to generate low-molecular-weight derivatives with improved selectivity (Norrby, 1993).
