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Ideally, the assessment of association of PFS/TTP and OS should be demonstrated over different stages of the disease (as the causal pathways of the disease process might differ depending on the stage) and across classes of drug (as drugs with different modes of action may have different pathways of intervention) (Fleming and DeMets, 1996).
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Since the synthesis of nucleotides has different pathways in mammals as compared to parasites, DHODH has gained much attention as a promising target for drug design.
The data is broken down in recognition of the fact that doctors, nurses and other health professionals have different education pathways, scopes of practice, and hence, their mobility potential will vary widely.
Direct replication in some of the loci showing significant differences in associations according to ER or PR status provides further support for the hypothesis that intrinsic subtypes of breast cancer should have different etiologic pathways; thus, the polygenic component of these subtypes of breast cancer should be different [ 27].
One of these studies targeted the upper-limb muscles, which may have different physiological pathways operating for control of muscle action compared with postural muscles such as the quadriceps in the lower limb.
These exclusion criteria will be applied as these patients are considered to be a different population and will have different care pathways and require different measures of quality.
Nevertheless, research shows that children may have different developmental pathways to achieve their own level of motor competence [1].
Tsubouchi et al. [ 78] have proposed two different pathways of homology searching during meiosis.
In boar, immunological and histological studies have described the different pathways of secretion and reabsortion of vesicles at the cellular level [ 5].
Studies in Bacillus subtilis have discovered two different pathways of teichoic acid biosynthesis, in two strains W23 and 168 respectively, namely teichoic acid ribitol (tar) and teichoic acid glycerol (tag).
Our current survey enabled us to recognize many important kinase splice variants which might be involved in diverse signal transduction pathways and have different modes of regulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com