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To further validate the conclusion that the structure that we have determined of the unlocked state represents a release intermediate, we designed a second mutational variant to stabilise the unlocked state, rather than destabilising it as the N44A mutation.
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As a result we have determined kon of Gq for the first time.
Previously, we have determined structures of the hydrophilic domain in several redox states.
Bucking the Trend Simple demographics have determined much of the sport's staying power.
Upon completion, we have determined sets of overlapping clones and their relative ordering called clone contigs.
Factors that may have determined choice of therapy were not available to us for analysis.
Previous studies have determined many of the signaling pathways activated by GM-CSF or M-CSF.
We have determined blocking of DNA replication by various other N-acetylarylamine and arylamine deoxyguanosine adducts.
Pathologists have determined that most of the victims died of starvation, exposure or communicable diseases.
We have determined the structure of plasma fibronectin by electron microscopy of shadowed specimens.
Various groups of researchers have determined the crystal structure of the kinase domain.
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CEO of Professional Science Editing for Scientists @ prosciediting.com