Sentence examples for have demonstrated up from inspiring English sources
These improvements have demonstrated up to 50% reduction in energy and doubling the lifespan of the bulbs.
Applying mouse transplantation models, we have demonstrated up to 100% survival of both heparanase treated and heparanase over-expressing mice, likely attributed not just to the above described improved engraftment, but primarily to a marked suppression of GVHD.
Some studies have demonstrated up to 70% overexpression of cytoplasmic HER-2 [ 10, 11].
Clinical trials with the phentermine/topiramate combination have demonstrated up to an 11% decrease in body weight when administered to obese patients.
In contrast to the cross-sectional studies, five case-control studies since 2008 have demonstrated up to an approximate doubling of diabetes risk in people receiving antidepressants.
Nevertheless, several clinical studies have demonstrated up to 93% clinical cure rate in S. saprophyticus AUC because of high pivmecillnam concentration in urine [ 26- 31].
We have demonstrated, for example, that over-expression of the heparanase gene and even exogenous addition of recombinant heparanase, up-regulate the expression of VEGF [51] and tissue factor [60]. Applying the hpa-tg and Hpse-KO mouse models, we have demonstrated up-regulation [60] and down-regulation (our unpublished results) of tissue factor levels, in vivo.
Immunoelectron microscopic studies have demonstrated up-regulation of CD31 and CD34 and show type IV collagen expression in lymphangiomas [ 38].
Observational studies in patients with IPF have demonstrated up-regulation of Fas and Fas-signaling molecules in epithelial cells compared to normal controls [ 69, 198, 199].
Gene expression studies have demonstrated up-regulation of transcription products primarily related to fatty acid metabolism, e.g., β-oxidation pathways, as well as cytochromes P450 and some hormonal regulatory gene transcripts.
Previous studies have demonstrated up-regulation of the PI3K/AKT/mTOR pathway as a mechanism of resistance to hormone therapy [ 35– 40], and clinical trials combining hormone therapy with mTOR inhibitors have shown promise in breast and endometrial cancers [ 41– 41].
