The human experimental studies have demonstrated the potency of PACAP38 as a pharmacological "trigger" of migraine-like attacks [29, 34, 44, 49, 54].
Regarding the relaxation of smooth muscle that lines airways of mammals, some boron-containing adducts have demonstrated greater potency and efficacy compared to well-known boron-free compounds.
In conclusion, we have demonstrated the potency of an HCMV immunoevasin to completely downregulate MHC class I expression on the surface of culture-expanded primary hMSCs.
AZD6244 and AS703026 have demonstrated improved potency when used in combination with other anti-MM agents.
Third-generation aromatase inhibitors have demonstrated greater potency and selectivity than the first-generation compound aminoglutethimide [ 49].
Several independent studies have demonstrated the potency of developmental mesenchyme and microenvironments in normalising the growth and differentiation of tumour epithelia (Abbott et al., 2008; Hayashi and Cunha, 1991).
Using different generations of SERMS (i.e., tamoxifen, raloxifene, or toremifene), several studies have demonstrated the potency of these drugs for the prevention of CRPC in vitro and in preclinical studies carried out in rat or mouse models [ 20– 20].
Studies comparing the activity of 13- cis retinoic acid (13cisRA) and all- trans retinoic acid (ATRA) in NBL cell lines have demonstrated similar potency of these retinoids, in terms of cellular differentiation, growth arrest and regulation of markers such as MYCN (Thiele et al, 1985; Reynolds et al, 1994; Veal et al, 2002).
LPL is intricately coupled to the very-low-density lipoprotein receptor (VLDL-receptor) and investigations have demonstrated the potency of the VLDL-receptor to bind lipoproteins and act as an anchor [6], facilitating the lipolysis of lipoprotein particles to release NEFA and thus generating a high local concentration at the endothelium.
