Sentence examples for have demonstrated essential from inspiring English sources

Despite this, it is clear that many transposable element-derived DNAs have evaded host-mediated epigenetic silencing to remain expressed (domesticated) in mammalian genomes, several of which have demonstrated essential roles during mammalian development.

Various studies have demonstrated essential roles of SNX1/SNX2 and SNX5/SNX6 for retromer activities in a variety of cellular functions, including the recycling of cargo proteins Vps10p in yeast, the phagocytic receptor CED-1 in C. elegans and mammalian CI-MPR.

Our previous study has demonstrated essential roles of presenilins in memory and neuronal survival.

Results obtained have demonstrated that essential information can be achieved by carrying out backward uncertainty propagation analysis.

But recent events, such as the attacks on the World Trade Center and the engulfment of New Orleans, have demonstrated how essential it is for public agencies to be well run, too.

Analyses of genetically engineered mice lacking otoferlin have demonstrated an essential role for this protein in vesicle exocytosis at the inner hair cell afferent synapse.

Our previous studies have demonstrated the essential roles of the transcription factor Sox9 in the commitment of mesenchymal cells to a chondrogenic cell lineage and in overt chondrogenesis during limb bud development.

Using mutational analysis, activity based assays, NMR and X-ray crystallography, we have demonstrated the essential role of a C2HC ZnF for the interaction of RNF125 with the E2, which originates from the requirement of the C2HC ZnF for the structural stability of the RING domain.

While the earliest studies of miRNA function in the immune system have demonstrated an essential role for miRNAs as a whole, later studies have focused on the contribution of specific miRNAs to specific immunologic processes.

Iwamoto and co-workers have demonstrated the essential role of glycosphingolipids in RANKL-induced osteoclastogenesis [32].

Gene ablation studies of Jmjd6 in mice and zebrafish have demonstrated its essential role in cell differentiation and development [22], [26] [28].