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Consistent with the first limitation, this may also have contributed to an underestimation of the magnitude of the 'active' hyaluronidase effect.
There are several examples of placebo-controlled trials in which the uptake of other active treatments differed by randomized group, and where this may have contributed to an underestimation of treatment effect or failure to detect a significant effect for some outcomes.
All these biases may have contributed to an underestimation of severe morbidity.
If so, this might have contributed to an underestimation of the association between poor social capital and mortality.
Inaccuracies in BMI determination may have contributed to an underestimation of association with T2D risk in our study.
31 A few other limitations might have contributed to an underestimation of the true associations of smoking with cardiovascular outcomes.
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The scarcity of research focusing on zootherapy has contributed to an underestimation of the importance of zootherapeutic resources in Brazil, although studies in this area have become more prevalent in recent years, at least at a global level.
The documentation was partially retrospective, which may have contributed to a recall bias and underestimation of HZ incidence.
This may have contributed to a local culture of vaccination [ 21], which goes along with the underestimation of the need to vaccinate the child for specific diseases.
A technical factor altering the IR of Aβ peptide may have contributed to this underestimation: the use of heat enhances the visualisation of IAβ, but formic acid impedes it [ 70, 71, 238].
Incomplete participation in the exercise programme might also have contributed to underestimation of the programme's effectiveness.
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