The variety, volume and velocity of the data may have changed, thus making the discipline more data driven than previously, but the fundamental statistical issues about representativeness and uncertainty in trade-off with practicability, ethics and privacy remain the same.
When cells, tissue blocks or their sections have been stored after dehydration, the structure of the proteins in the cells will have changed thus affecting the binding of antibodies.
Another possibility is that in this clade, the binding site motifs and the transcription factor DNA binding specificity has changed; thus, the TFBSs are no longer recognizable.
If the solutions take too long to be reached, premises and prevailing conditions on which the original problems were designed may have changed considerably, thus rendering the purported solutions unusable.
Nevertheless, it is possible that only some of these implicated environmental factors have changed and, thus, only these particular factors may be responsible for the changes that have taken place in MS epidemiology over the past several decades.
This suggests that the regulation of these responses may also have changed and thus the transcription factors underlying these responses and the cis-elements that define transcript abundance were analysed to determine if they also displayed significant differences.
The reason for choosing this model was: some of the participants were undergoing rehabilitation and could have improved, and if they had been tested on two different days within a week, their performance could have changed and, thus, test-retest reliability would have been biased.
In order to assess the effect of this study on the pooled result, a post-hoc sensitive analysis was performed to calculate DOR for ACS in the meta-regression model without the studies by Eschwege et al. and De Vegt F et al. In addition, the diagnostic criteria for DM have changed over time, thus the criteria used in the included studies has varied.
The trapping method of CO2 with airtight plastic container for 7 days may have changed soil microenvironment and thus soil respiration.
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