Sentence examples for have caused difficulty from inspiring English sources

We explain the major technical challenges that have caused difficulty with predicting novel ligands, including the problems of sampling noise and the challenge of using benchmark datasets that are sufficiently unbiased that they allow the model to extrapolate to new regimes.

The 'Sorrow of Bihar' Floodwaters have caused difficulty in large parts of the eastern Indian state of Bihar since an embankment ruptured at Kusaha in neighbouring Nepal on 18 August.

More importantly, a personal administered questionnaire might have caused difficulty in maintaining anonymity and it might have influenced the patients to give more positive answers than they really meant just by been handed the questionnaire by the specialist and care-provider.

The dysmetric limb movements were also not considered to be so severe that they would have caused difficulty in rising - cerebellar diseases do not cause loss of muscle strength [ 40] - although rising with the forelimbs first, which was seen occasionally, is suggestive of some inability to coordinate the movements to stand.

Duke's expressions of support for Donald Trump have caused difficulties for the Republican presidential candidate.

Mr. Portnoy of Morningstar also declined to name companies whose plans have caused difficulties for fund managers.

"The judgment will resolve many outstanding matters between the two states and provide a way forward for both in areas which have caused difficulties in the past," a government statement said.

The second is that recent turmoil in the capital markets may well have caused difficulties for some of the commercial banks that have been rapidly expanding their investment-banking businesses in recent years.

"The judgment will resolve many outstanding matters between the two states and provide a way forward for both in areas which have caused difficulties in the past," Musa Elayo, an official in the Nigerian Justice Ministry, said in a statement released by the presidency.

Commonwealth Games organisers have vowed to learn the lessons of ticketing and security problems which have caused difficulties at the Olympics.

Because the subject matter involved the mistress of a Neapolitan king, and may thus have caused difficulties with the Italian censors, Donizetti decided that the opera should be presented in France.