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Significant predictors found have been size [ 10, 14- 16, 20], location [ 9- 11], and endobronchial visibility [ 18].
However, most RNA-seq datasets published thus far, including large-scale projects like modENCODE, have been size selected to exclude abundant medium-size (75 to 300 nt) noncoding (nc RNAs, such as the spliceosomal snRNAs.
The disease is associated with the presence of double-stranded RNA (dsRNA) molecules, 26 dsRNAs have been size separated, and up to 16 have been found in a single sample (4).
The reported predictors of positive samples have been size [ 6, 9- 16], location [ 10, 13, 14, 17], visible lesion, compression or constriction [ 12, 18, 19], CT bronchus sign [ 13, 17, 20], fuzzy or sharp border [ 11], the use of a C-arm fluoroscope [ 8, 21], and sampling technique [ 11, 14, 15, 18, 22- 29].
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