Sentence examples for have been refractory from inspiring English sources

In summary, we herein present a novel solubility enhancing fusion tag that allows bacterial expression of a panel of pharmaceutically relevant peptides and proteins with different biochemical properties that previously have been refractory to recombinant production.

The first is the amazing state of science today, and medicine and computational biology and engineering, which come together to make it possible now to make drugs for diseases that up until now, have been refractory.

This novel method of gene silencing has substantial promise for elucidation of gene function in bacterial species that have been refractory to experimental introduction of exogenous DNA.

These methods may be broadly applicable to the production of biosynthetic enzymes from other natural product biosynthetic gene clusters, especially those that have been refractory to production in heterologous hosts despite standard expression optimization methods.

Abnormalities in emotional processing are common in human neurological diseases, but have been refractory to study in rats and mice, and are difficult to study in non-human primates.

So far, CHB patients have been refractory to many therapies that were effective in animal models [ 25].

HIV-1 has been refractory to vaccine technologies thus far, although select human antibodies can broadly neutralize HIV-1 by targeting sequences of the gp41 juxtamembrane fusion apparatus.

Radiofrequency denervation is commonly used for the treatment of chronic facet joint pain that has been refractory to more conservative treatments, although the evidence supporting this treatment has been controversial.

To this end, the Translational Behavioral Science Research Consortium was created by the National Heart ,Lung, and Blood Institute to identify promising, but underutilized findings from basic behavioral science that might have potential application for translation to clinical populations where behavioral change has been refractory to standard intervention approaches.

The recent introduction of tumor necrosis factor (TNF) blockers in the treatment of spondyloarthritis has offered the most hope in not only relieving symptoms and signs of both peripheral arthritis and enthesitis but also spinal disease, which often has been refractory to other agents.

The symptoms had been refractory to non-operative management.