Global incidence and mortality have been less thoroughly evaluated.
CT and US have been less well evaluated in children than in adults, but there is increasing data on imaging use in the paediatric population.
Although angiotensin-II receptor blockers (ARBs) have been less extensively evaluated, theoretically they may have "protective" effects similar to those of ACE inhibitors, but with better tolerability.
Other biologic agents have been less thoroughly evaluated.
More subtle long term effects, such as those on metabolic disease and neurobehavioral outcomes, have been less comprehensively evaluated.
Although the safety and efficacy of colesevelam have been well documented in the general population, its safety and efficacy have been less extensively evaluated in older patients.
Other agents such as danazol, aromatase inhibitors, and oral contraceptives have been less extensively evaluated and, therefore, their use cannot be recommended at this time.
Myelography, discography and/or root blocks are used to confirm symptomatic discs and/or roots but these procedures have been less thoroughly evaluated and may not be considered gold standards for detecting nerve involvement [ 54].
However, LDL is comprised of a spectrum of distinct particle subclasses differing in metabolic properties and atherogenic potential (2), and effects of saturated fat on these subclasses have been less extensively evaluated.
Therefore, further studies should be performed to evaluate the reliability of subtests that have been less frequently considered to date.
