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Since that time, several studies evaluating the efficacy of such hybrid approaches have been published, but few have been efficacious.
Moreover, while anthelmintics have been efficacious in the past, evidence of rapidly emerging anthelminthic drug resistance is mounting7,8.
We draw on AOS, and other publications, to identify significant contributions that have been efficacious in theorizing changes in MCS with a particular concern for the context of innovation within which this takes place.
However, the patient from whom PDX #11 was derived subsequently received single-agent rucaparib with starting dose of 600 mg twice daily and had a partial response (PR) of 10 months as demonstrated by Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1) (Fig. 3f, g), suggesting that in the PDX, a higher dose of rucaparib treatment in vivo may have been efficacious.
Glucagonlike peptide 1 (GLP-1) receptor agonists have been efficacious for the treatment of type 2 diabetes due to their ability to reduce weight and attenuate hyperglycemia.
G00033054 and GDC-0973 are potent and selective MEK inhibitors that have been efficacious in treating KRAS and RAF mutant cells [29].
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In clinical trials alcohol brief intervention (BI) in adult primary care has been efficacious in reducing alcohol consumption, but we know little about its impact on health outcomes.
Since 1995, The National Parks Board (NParks) in Singapore has been efficacious in propagating and reintroducing G. speciosum in its orchid conservation programme (Yam et al. 2010).
Until now, one of the most important unmet needs in multiple sclerosis treatment has been efficacious oral therapy.
Another concern relates to low-dose prednisone therapy, which has been efficacious in preventing structural damage progression [ 50- 52].
Anti-TNF-α treatment has been efficacious for the treatment of refractory ocular inflammatory disease [ 7, 14– 14].
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