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As CDKs are critically involved in regulating the cell cycle and their abnormal activities contribute to tumor genesis, often through interaction with pathways regulated by oncogenes and tumor suppressors, they have become valid targets for developing chemical inhibitors for cancer therapies[17] [19].
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"Behind the Music" and Us Weekly and Just Jared have become as valid paths to renown as roles on TV shows and in films.
As a significant amount of research is being conducted to advance sustainable practices for road pavements, foaming asphalt mixes have become a valid option to common asphalt paving technologies.
Traditionally, radical cystectomy has been the mainstay, but as evidence accumulates for the benefit of perioperative therapy, neoadjuvant or adjuvant cisplatin-based chemotherapy have become more valid options for MIBC patients [ 3– 13].
Nonetheless, these null results should be taken with caution, in part because the dualism scale may have become a less valid measure of dualist beliefs in recent years.
Their valid ideas have become Kemalist political slogans.
In the sense of "genuineness" or "valid credentials," it seems to have become a political buzzword — candidates in the Republican primaries were constantly showing their "conservative bona fides".
The goal of this paper is to re-evaluate these rules and to establish if they are still valid today or if they have become urban legends.
Valid and reliable measurements of VT-HRQ have become essential to the assessment of disease status and treatment effectiveness in ocular disease [ 11].
As social networks have become stable tools used by billions, any combination or style of engagement with them has become inherently valid.
So they have become allies of the immigrants and the Mexican government in pushing for recognition of Mexican-issued consular cards as valid identification.
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