Exact(6)
Among the 26 drugs, 22 have ATC classifications.
Among those other drugs, 594 have ATC second sublevel classifications.
Some of the prescribed fixed dose combinations (FDCs) are not listed by the WHOCC, and therefore do not have ATC codes.
Additionally, the correlation between Score_S and Score_R was 0.546 if we only considered the drug-target associations in which the drugs have ATC codes.
Drug combinations that do not have ATC codes for the corresponding drug components and combinations with none or unclear efficacy were discarded.
If these non-SCZ drugs have ATC classification annotation, physicians may consider whether the characteristics of non-SCZ drug categories have a higher probability to cause adverse drug-drug interactions with SCZ drugs.
Similar(54)
Based on the drug's ATC annotation from DrugBank and KEGG, among the 303,018 drugs in WinDTome, 1,856 had ATC codes, of which 1,502 drugs had one ATC code while 354 drugs had multiple ATC codes.
Of the 85 phenotypically resistant isolates, 56 (66%) were also correlated by the presence of resistance mutations in the katG gene; 47 of these isolates had ACC, 6 had AAC, 2 had ATC, and one had CGC codon.
Of the 56 isolates with mutations, 47 had ACC (Thr), 6 had AAC (Asn), two had ATC (Ile), and one had CGC (Arg) substitution at codon 315 (Table 1).
Table 2 shows the numbers of drugs, targets, and drug-target interactions and the average Score_R in each group of Score_S of WinDTome and those in the subset with drug having ATC code. Figure 2A and Figure 2B show the distributions of Score_S and Score_R, respectively.
As in the prevalence of any psychotropic medication use, concomitant use with ATC-MS data was adjusted by excluding individuals who had ATC-MS dispensed but no other psychotropic medications during the study year.
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