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While EBV-infected BL31 and LCL cells both resemble activated blasts, they have approached this phenotype from opposite ends of the germinal centre reaction.
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Biologists from different subdisciplines have approached the study of phenotypes in different ways.
Andrew had this phenotype too.
To circumvent this limitation, we have developed a phenotype discovery approach termed global transcription machinery engineering (gTME) that allows for the generation and selection of nonphysiological traits.
In contrast, FGF7-knockout mice have no SMG phenotype, so this phenotype may be compensated by other pathways39.
However, more recent approaches have given more interpretable phenotypes.
Our simulations suggest that model selection approaches have difficulty ordering the phenotypes when the QTL effect reaches the truly reactive gene by two or more distinct paths, only one of which is mediated by the truly causal gene (see Figure S1C, for an example).
Moreover, because mammary tumor microenvironment is rich in tumor-associated macrophages, which express CSF-1R (they have resident-type macrophage phenotype [ 26]), this approach could also affect tumor-associated macrophages that are an important element in cancer development and invasion.
We have adopted a phenotype-driven approach to investigate the effects of dietary garlic on erythropoiesis in a mouse model.
We have followed this approach and have applied functional genomics methods to compare global transcriptional signatures of psoriasis phenotypes in humans and five psoriasis mouse models.
Here, we have expanded this approach to a larger, unbiased screen to identify further modifiers of the dominant CLN3 phenotypes.
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