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Why have these changes occurred?
How have these changes occurred?
Or have changes occurred in discrete, quantum steps?
Recent surprise that cancers have as many as 10,000 mutations [ 5, 6] is thus entirely misplaced: the tumour progenitor cell may already have this many mutations before any genetic changes occur during tumorigenesis.
On the other hand, only small, if any, changes have occurred in Greater Stockholm during this period, and these changes probably do not have an effect on the general picture of the route environment [cf. [ 14]].
"We have not really had any insight into whether those cancerous changes occur in normal cells as well, a treatment that kills 20-30% of normal cells would potentially be a lot of collateral damage," Dr Campbell said.
We have also assessed whether any changes that occurred in this period were differential between the urban and rural areas of the island.
We applied a large cancer registry database to determine whether any changes had occurred in the incidence of conjunctival melanoma.
We compared to ICNARC data & the local results from 2008 to assess how the unit is performing regarding patient outcomes & to see what, if any, changes had occurred since 2008.
Our study objectives were to determine whether any changes had occurred in the prevalence of canine leishmaniasis over 22 years and to identify risk factors for this disease.
Finally, we explored whether any changes had occurred in the focus and terminology of the identified themes in step 4 between the two periods.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com