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The increasing frequency and variety of resistance patterns have also necessitated the introduction of definitions for 'extensively drug-resistant' pathogens (non-susceptibility to at least one agent in all but two or fewer antimicrobial categories) and 'pandrug-resistant' pathogens (non-susceptibility to all agents in all antimicrobial categories) [ 30].
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Furthermore, the widespread development of Internet viewers has also necessitated the transfer and display of large-scale CAD models over networks.
On one hand, this increase in software has made embedded systems more accessible and easy to use, while on the other hand, it has also necessitated further research on how a complex, real-time, embedded software can be designed automatically and correctly.
The advent of biosimilars 92 has also necessitated the development of new guidelines specifically for such products and will be another area requiring careful regulation and monitoring.
Studies have also documented that obesity necessitates an emergency Caesarian section [ 10, 18, 50].
Product complexity has also increased, necessitating larger engineering teams with more sophisticated product design strategies.
Other trials have also found a higher rate of recurrence necessitating further treatments.
Moreover, in addition to biosimilars, some reference products have also been associated with adverse drug reactions, which necessitate their inclusion in any intensive pharmacovigilance program.
The stigma in the opera world regarding vocal surgery, which the soprano Natalie Dessay and the tenor Rolando Villazón have also had, stems partly from accusations that it is necessitated by improper technique, Ms. Radvanovsky said.
The cytoskeletal modifications necessitated by their large size and dynamic microtubule-driven reticulopodia have also made them favored targets for cell-biology investigations [ 5- 7].
Citigroup and UBS have also raised tens of billions of capital only to have more big write-downs, necessitating the need to raise more capital.
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