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However, the accumulative effects observed in the present study indicate that both 'being poor' and 'feeling poor' together are factors that combined have aggravating effects on mental health.
It was surprising that Scn1afl/+, VGAT-Cre mice show a greater premature mortality rate than constitutional heterozygous Scn1a knock-out mice (for a comparison, see Figs 1F and 3F), raising the possibility that remaining Nav1.1 in excitatory neurons of Scn1afl/+, VGAT-Cre mice may have aggravating effects on seizure-related sudden death.
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The results of the analyses for MetS development were relatively close to clinical observations: together with other risk factors, hypertension had aggravating effects on the cardiovascular risks [ 34].
Part of the pro-atherogenic effect of IL-18 may be indirect since IL-18, in particular in combination with IL-12, is a potent inducer of the production of IFN-γ, which has aggravating effects on atherosclerosis (see below).
Multiple mediation analyses confirm that media violence exposure and homework, respectively, can have aggravating and attenuating effects on self-reported aggression.
However, users have aggravating difficulties in utilizing the potentials of desktop GeoVEs because of navigation and wayfinding constraints.
Our findings contrast with the experience studying murine collagen-induced arthritis, in which prior exposure to HgCl2 did not influence the outcome of the arthritis, but exposure following the onset did have an aggravating effect on the arthritis [ 29].
Perceived unmet preferred condition to testing had unadjusted aggravating effect on refusal of PIHT with COR (95% CI) = 1.20 (1.20–1.20).
Moreover, whereas SAC knockdown had an aggravating effect on the phenotype of condensin/cohesion, the latter relied on a functional APC/C.
Future studies should investigate the mechanism of how ASD-bound PAHs induce their aggravating effects.
Third, several well-controlled trials have clearly documented an aggravating effect of neuroleptics on physical withdrawal signs, precipitating seizures and increasing mortality rate [ 41].
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