Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis.
Inhibitors of activated tyrosine kinase, COX-2, metalloproteases, and polyamine synthesis should also have activity in ER-negative as well as ER-positive tamoxifen-resistant precancerous tissue.
"This was important, to have activity in the brain.
"You may have activity in Syntagma Square," Mr. Petropoulos said.
This therapeutic agent was specifically designed to have activity in model systems resistant to conventional taxanes.
This finding may help explain the observations that antifolate drugs have activity in the treatment of mesothelioma.
Despite the large influx of Asian-Americans, Ms. Bae laments the lack of political activism, noting "there is a lot of first-generation Asians here, but they only have activity in a small way through church or some little organization".
In conclusion, BV may have activity in treatment of steroid-refractory cGVHD, yet its use is limited by treatment-emergent toxicities, including peripheral neuropathy.
Then, reducing the band gap of the titania, it will have activity in the entire visible spectrum, and its applications increase considerably.
It appears to have activity in tumors believed to be marginally sensitive to the other platinum agents, and it is neither ototoxic nor nephrotoxic.
This series is non-peptide, low molecular weight, and analogs have activity in a cell fusion assay with EC50 values ranging 3 41 μM.
