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However, genes that are members of functionally redundant gene families, or genes that have a vital function and therefore result in lethal mutant phenotypes, are difficult to identify.
Because the three proteins, Bik1p, Bim1p and Kar3p, are known to act on kinetochores and interpolar MTs [24], [25], [26], [27], the observed synthetic lethality with SA and SE mutations indicate that β tubulin Ser172 may have a vital function inside the spindle.
Stronger binding sites could be under higher selective pressure, since they are more likely to have a vital function.
COX-2 is an inducible prostaglandin G/H synthase and was identified to have a vital function in prostaglandin (PG) synthesis.
In addition to playing important roles in cellular and bodily functions, n-3 and n-6 are precursors to eicosanoids that have a vital function in regulating inflammatory processes (Wall et al, 2010).
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I feel it strengthens the belief in the church as having a vital function -- by penetrating the ground, by turning it into a rigorous tool.
The results of this study indicate that GO has a vital function in catalyzing the photo-Fenton process.
Among the all parameters applied for determining the feasibility of a particular CO2 EOR project especially in the miscible mode, solubility of CO2 has a vital function in the design and simulation of the CO2 injection.
SLC11A1 gene has a vital function in the pathway of macrophage activation [20].
Furthermore, we show that Am-tra2 has a vital function in embryogenesis that differs from its reported functions in other species.
Our in vitro and in vivo data demonstrate that KDM5C has a vital function in promoting cell mobility, which is partially by the regulation of BMP7 expression.
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