Elucidating the hereditary component has proven difficult because multiple genes seem to produce a susceptibility to developing endometriosis.
Patients with a heterozygous mutation of CCM3 have a high susceptibility to develop cerebral cavernous malformations, and it has been shown recently that they can also develop meningiomas, which places CCM3 as a possible tumor suppressor gene (Clark et al., 2013; Riant et al., 2013).
In the absence of functional p53, these knockout mice have a higher susceptibility to develop carcinomas.
Additionally, patients without genetic disorders but with serum anti-IFN gamma autoantibodies have a higher susceptibility to develop Mycobacteriosis [ 43].
Spontaneous tumours arise at the same frequency as in wild-type controls; however, they do have a higher susceptibility to develop fibrosarcomas after chemical carcinogenesis (Ref. 38).
However, Neal et al. [ 39] showed that overexpression of SFN reduces the overall and disease-free survival of breast cancer patients and is able to predict which patients have a high susceptibility to develop metastasis.
Patients who inherit BRCA1 or BRCA2 mutations, have an increased susceptibility to develop breast and ovarian cancers, whereas FA patients can have congenital defects and are predisposed to developing leukaemia and various solid tumours.
Our results clearly indicate that paclitaxel-resistant untransformed human mammary epithelial cells have an increased susceptibility to develop aneuploidy in response to this agent.
In addition, individuals homozygous for MAPT H1/H1 have an increased susceptibility to develop PD compared to those bearing the heterozygous H1/H2 genotype [ 59].
The main limitations for the interpretation of this study are the high rate of dropouts and their sociodemographic characteristics, which ultimately may suggest that they have an increased susceptibility to develop PTSD.
