Because of the large surface area of interaction of the drug-immunophilin complex with calcineurin, FK506 and CsA have a specificity for their biologic targets that is equivalent to growth factor-receptor interactions.
These scenes could be tediously predictable but they usually have a specificity that imbues them with life, as when Zelda Fitzgerald, hovering between brilliance and madness, performs a lengthy balletic twirl with her pink tulip skirt rising to reveal black knickers beneath.
Our hypothesis was that based on previous studies on copeptin in other diseases, [29, 31 34] a cutoff of ≤ 5 pmol/l would have a sensitivity of ≥ 97% for ruling out serious secondary headache causes, and that a cutoff of ≥ 20 pmol/l would have a specificity of ≥90% for the presence of serious secondary NTH.
In a 3-year prospective study, initial clinical diagnosis of Parkinson's disease was found to have a specificity of 46% and sensitivity of 93% when compared to diagnosis after 3 year clinical follow-up, compared to 97% and 78% with an initial DaT scan (Cummings et al., 2011).
The initial diagnostic assessment must be aimed at ruling out SAH. Non-contrast brain CT is the first examination in this assessment, to be performed within the first 12 h after the onset of the headache, preferably using third-generation CT scanners that have a specificity of 98% and a sensitivity close to 100%[25]].
Thus, a test with no false negatives would have a sensitivity of 100%, while a test with no false positives would have a specificity of 100%.
