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This complexity is exemplified by the ELR+ CXC chemokine system, a large family of secreted proteins that have a prominent function in the development and progression of numerous inflammatory diseases, including rheumatoid arthritis (RA 2.
The abundance of sPLD-like-B isoforms suggests that they have a prominent function.
Also, these SVs have been shown earlier to be unable to reach the cell surface and therefore they are unlikely to have a prominent function.
miRNAs have a prominent function in homeostatic plasticity, such as apoptosis, cell proliferation, and differentiation, by fine-tuning the expression of several target proteins.
This distinct T helper cell lineage was discovered 5 years ago (Harrington et al, 2005) and have a prominent function in mucosal immunity and autoimmune diseases such as multiple sclerosis, as well as human inflammatory bowel disease and psoriasis.
Previous studies in Greek breast and/or ovarian cancer patients with family history have shown that four specific BRCA1 mutations, c.5266dupC, G1738R, and two large genomic rearrangements involving deletions of exons 20 and 24, have a prominent function in the population's BRCA1 and BRCA2 mutation spectrum.
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MicroRNAs have emerged as key regulators in T cell development, activation, and differentiation, with miR-181a having a prominent function.
Cathepsin B has a prominent function in mediating apoptosis potentiated by HDACi and doxorubicin combinations in myeloma.
Collectively, these findings underscore that DC-derived RA has a prominent function in the regulation of gut-associated immune processes.
Besides roles in HIV infection and RNA splicing, Tat-SF1 also has a prominent function in transcriptional elongation.
Thus, identifying such new pathways should provide attractive candidate prognostic markers and therapeutic targets for refractory breast cancers, in which mutant p53 has a prominent function.
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