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A potential problem with the weighting method of Laird and Mosteller is that it uses a normal approximation to proportions which might be problematic if the proportions are very small because they might not have a normal distribution anymore [ 33].
Just have a normal conversation.
A normal approximation to the binomial distribution has been used to determine the standard error in the mean.
Using a normal approximation the target standard error is approximately.05.05
By using the Binomial distribution rather than a normal approximation, falcon more effectively pools evidence from sites with low coverage.
The other approach is based on a normal approximation of a distribution associated with new mutations.
We suggest approximating the distribution of the sum of independent and identically distributed random variables with a Pareto-like tail by combining extreme value approximations for the largest summands with a normal approximation for the sum of the smaller summands.
In the case where a normal approximation is not accurate then other approximations to the cumulative probability distribution of the binomial must be used.
This approach is based on a normal approximation to the sampling distribution of log(R ^ ).
Confidence intervals were assumed to follow a normal approximation to the binomial distribution.
Hence using a normal approximation for these statistics is generally inadequate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com