However, none of the B. caballi infected donkeys showed clinical symptoms and it is possible to speculate that T. equi has a higher pathogenicity than B. caballi in donkeys as suggested for horses [ 16].
The recent H1N1/09 swine-origin influenza pandemic appears to have a high infectivity rate but low pathogenicity [1].
We have found that the pathogenicity proteins encoded by the pathogenicity genes tend to have a higher average degree than that of the whole network, reflecting their special biological roles in the organism.
The pathogenicity of NTHi is substantially lower and different than that of Hib [ 3], but in this outbreak an NTHi strain caused severe infections supporting the notion that some lineages of NTHi have a higher virulence.
A closer inspection revealed that two missense variants had a high probability of pathogenicity due to a specific combination of predictors: large PolyPhen probability, SIFT score close to 0, frequency absent and a moderate to large Grantham score.
In addition, the success of transmission is related to the virulence of the species involved; S. brasiliensis has a high degree of pathogenicity in both cat and human hosts.
Hepatitis C virus (HCV) infection has a high prevalence, incidence, and pathogenicity, and may evolve into cirrhosis and hepatocellular carcinoma (HCC) (Castello et al., 2010).
The p.R279C had a high functionality score as predicted by pathogenicity predictors (Table 1), whereas detailed in silico prediction analysis showed only a subtle order-enhancing effect (Fig. 4) consistent with the fact that this is a common variant with a modest effect size (OR = 0.64).
In a patient with LQTS for example, a variant in KCNQ1 (a gene implicated in a large proportion of LQTS cases) has a higher probability of pathogenicity than a variant in KCNJ5 (which has only been implicated in a handful of cases).
A total of 70 sequences had a high similarity to genes shown experimentally to play a role in pathogenicity in other fungi (Table 2).
Virus type 1-3-4 has previously been reported to be associated with higher than expected preweaning mortality [ 7], and it has been shown that a higher pathogenicity PRRSV isolate is more likely to spread by aerosol [ 13].
