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Unlike generic calpain inhibitors, Tat-K did not have a general effect on excitotoxicity-induced processing of alternative calpain substrates such as spectrin.
Some (such as the Gtf and MED factors) have a general effect on the transcriptional apparatus.
Finally, as Anx2 is a multifunctional protein, overexpression could have a general effect on cellular processes and only indirectly increase viral assembly.
PTK6 overexpression does not have a general effect on membrane-associated receptor tyrosine kinases in suspension, as levels of EGFR, previously reported to activate PTK6, were unchanged (Figure 6B).
Furthermore, the net change in surface charge due to loss of D-ala could have a general effect on the ability of the bacteria to exchange of cations and anions across the cell wall, and this could affect one of the TCRSs or other regulatory pathways.
These results suggest that DXR specifically affects the GAr-domain-dependent translation inhibition, whereas 5FU might have a general effect on translation.
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Mr Carnes gives generous credit to the geeks at ReD, saying that they have had "a general effect on everything .ReD has some curious methods.
MK212 also suppressed food retrieval, indicating that it has a general effect on motivated behaviors.
People's financial situation, and depressive and positive symptoms had a general effect on almost all subjective domains.
A study7 recently showed that PD-1 blockade activates specific T-cell subsets, rather than having a general effect on the entire population.
To investigate whether p16 p19 has a general effect on human somatic cells, we also expressed shp16 and shp19 in primary human epithelia cells from bronchus/trachea tissues of a 34-year-old female donor.
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