Sentence examples for have a fundamental function from inspiring English sources

This could suggest that the C2-FerI-C2 motif functions as a single entity and may have a fundamental function shared between metazoan and protozoan putative ferlins.

CCL21, together with other homeostatic chemokines such as CXCL13, has been shown to have a fundamental function in the development of secondary lymphoid organs by interacting with CCR7 [ 4, 33].

Inappropriate hedgehog signalling has a fundamental function in an increasing number of malignancies, including childhood solid tumours such as medulloblastoma and RMS (Evangelista et al, 2006).

Because deletion of tdp-1 perturbed the abundance of these transcripts, we hypothesized that TDP-1 has a fundamental function in the formation, or metabolism, of dsRNA.

Nevertheless, the widespread and relatively strong expression of the gene in both species suggests that the protein has a fundamental function(s) in cells of many, if not all, tissues.

We set out to investigate whether NM1 has a fundamental function at class II promoters, contributing to the maintenance of a chromatin state required for Pol II transcription activation.

Tight junctions (TJs) are a type of cell-cell adhesion that have a fundamental role for the BRB function because they regulate paracellular diffusion across epithelia [4].

The 'pericentriolar satellites' have a fundamental role in the regulation of the centrosomal anchoring function.

Reviewer 2: Dr. Benedita Rocha, Institut National de la Santé et de la Recherche Médicale (INSERM) U591, Insitut Necker, France Reviewer's comment: Regulatory cells have a fundamental role in many disease processes, and extensive experimental and clinical data indicate that tools preventing or increasing regulatory function will have a fundamental therapeutic role.

The central cholinergic system has a fundamental role in normal cognitive function, and in diseases that exhibit cognitive dysfunction.

It is suggested that gene duplication has a fundamental role in diversifying gene function[ 45].