Sentence examples for have a functional consequence on from inspiring English sources

SNPs belonging to ROBO1 and LPHN2 were also located within intronic sequences, but were not predicted to have a functional consequence on gene expression and/or function.

Immunofluorescence was used to determine the presence of the CXCL12 receptor, CXCR4, and the FGF10 receptor, FGFR2, on 3D BPH-1 acini, to prove that these growth factors can have a functional consequence on the acini (Figures 5B and 5C).

Does reduced aggression following sleep deprivation have a functional consequence on reproductive fitness in a competitive environment?

Spinal electrophysiological experiments were then undertaken to determine whether the increase in spinal TRPV1 immunoreactivity has a functional consequence on neuronal responses in the MIA model.

Currently, there is no evidence to suggest that any of the polymorphisms examined has a functional consequence on the biological activity of 5-HT1DR and OPRD1 [ 124].

These polymorphisms may have a functional consequence.

Based on the above, we hypothesized that the loss of the self-renewal marker HMGA2 would have a functional consequence in adult Wnt10b −/− mammary cells to generate mammospheres.

Therefore, the deletion observed in the cytoplasmic tail of IFNGR1 in AGM as compared to macaque might either not have any functional consequence on this pathway or give to this species a yet unknown evolutionary advantage.

The PON1 Q192R polymorphism in particular has been shown to have a strong functional consequence on the relative rate of hydrolysis of certain organophophate substrates (Li et al. 2000) and has been shown to affect the catalytic efficiency for chlorpyrifos but not diazinon (Richter et al. 2009).

Together the lack of significant effect of T1410 mutation on dimerization and kinase activity indicate that it does not have a major functional consequence on LRRK2's phosphorylating activity towards other substrates.

The rest of the residues at both complex interfaces had ΔΔGbind values >0.1 kcal/mol, which suggests that their mutation to Ala does not have any functional consequences on the formation of complexes.