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Mammalian Shaw homologues have been shown to have a central function in clock neurons, and were recently demonstrated to be the first circadianly-regulated intrinsic voltage-gated currents in mammalian cells [21].
It indicates that miRNAs are essential regulatory elements for mechanisms that ensure correct axon guidance decisions at the midline and thus have a central function in the establishment of circuitry during the development of the nervous system.
Sequential activation of caspases can have a central function in the execution phase of cell apoptosis.
Particularly the Kupffer cells have a central function in hepatotoxicity (Roberts et al. 2007).
The entoproct enrolling muscle may have a central function during metamorphosis, when the larva has already settled.
Some of these DC-derived lipids, in particular retinoic acid (RA), have a central function in shaping T-cell development and effector functions.
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The liver has a central function in transforming and clearing chemicals but it is susceptible to the toxicity from these agents.
The liver has a central function in lipid metabolism by repartitioning FFA derived from body fat stores and integrating dietary FFA into whole body fuel oxidation and energy storage via secretion of lipoproteins.
By controlling the expression of cytokines, chemokines, anti-bacterial peptides and adhesion molecules, the transcription factor nuclear factor-kappa B (NF-κB) has a central function in this process.
Thus, UHRF1 has a central function in epigenetic transcriptional regulation.
β-Catenin, which links cadherins to the cytoskeleton, has a central function in these signaling circuits.
More suggestions(15)
indicated a central function
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have a heuristic function
have a central clearinghouse
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have a central originality
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com