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It is therefore plausible that mucins have a broader function across species and organs than previously anticipated.
Therefore, the pepM gene in L. plantarum may have a broader function, probably utilizing proteins and peptides as methionine pool, in addition to the classic PepM function for N-terminal maturation of proteins.
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Hence, association with these four Rab proteins suggests that C9ORF72 may have a broad function in facilitating endocytic trafficking events.
Although the mode of action shared similarities, Kaiso did not associate with the p120-REST-CoREST complex, suggesting that nuclear p120 might have a broad function in the regulation of transcriptional repression.
Pkh-kinase regulation of endocytosis could thus potentially be used to selectively adjust the composition of the plasma membrane, suggesting that sphingolipid signaling might have a broad function in organizing the plasma membrane.
Other hematopoietic cell types, such as platelets [ 64], eosinophils [ 65], and hematopoietic progenitors [ 66], also participate in angiogenic processes, but it remains to be established whether they can directly promote tumor angiogenesis, rather than having a broader function in supporting tissue inflammation and remodelling.
Involving the CAB in the more substantive aspects of the research endeavour will allow them to have a broader role than functioning as a link between the research team and the community for the sharing of information.
It has a broad function in cellular processes like plasma membrane fusion, pheromone signaling or protein sorting [ 24- 26].
Gil et al. [ 96] have proposed that the gyrase in Buchnera might have acquired a broader function and has become capable of removing or introducing negative supercoils, as suggested previously by Drolet et al. [ 97] in E. coli.
Modern pharmacological studies have proved that H. sinensis contains various active ingredients which have a broad therapeutic function [ 5, 6].
Recent insights suggest that MMPs may also have a broader spectrum of functions including regulation of the inflammatory response, for example through effects on chemokine and cytokine signaling and by release of neoepitopes from the ECM (Pearce and Shively 2006).
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