Hence, association with these four Rab proteins suggests that C9ORF72 may have a broad function in facilitating endocytic trafficking events.
Although the mode of action shared similarities, Kaiso did not associate with the p120-REST-CoREST complex, suggesting that nuclear p120 might have a broad function in the regulation of transcriptional repression.
Pkh-kinase regulation of endocytosis could thus potentially be used to selectively adjust the composition of the plasma membrane, suggesting that sphingolipid signaling might have a broad function in organizing the plasma membrane.
It is therefore plausible that mucins have a broader function across species and organs than previously anticipated.
Therefore, the pepM gene in L. plantarum may have a broader function, probably utilizing proteins and peptides as methionine pool, in addition to the classic PepM function for N-terminal maturation of proteins.
It has a broad function in cellular processes like plasma membrane fusion, pheromone signaling or protein sorting [ 24- 26].
Other hematopoietic cell types, such as platelets [ 64], eosinophils [ 65], and hematopoietic progenitors [ 66], also participate in angiogenic processes, but it remains to be established whether they can directly promote tumor angiogenesis, rather than having a broader function in supporting tissue inflammation and remodelling.
Involving the CAB in the more substantive aspects of the research endeavour will allow them to have a broader role than functioning as a link between the research team and the community for the sharing of information.
Modern pharmacological studies have proved that H. sinensis contains various active ingredients which have a broad therapeutic function [ 5, 6].
The ced-3 caspase has been well-characterized for its role in apoptosis but not demonstrated to have a broad, non-apoptotic function in development (Yuan et al., 1993; Xue et al., 1996; Conradt and Xue, 2005; Peden et al., 2008).
Besides proliferation, HuR was shown to have a broad pro-survival function, by binding to mRNAs encoding anti-apoptotic proteins like prothymosin α, sirtuin 1 (SIRT1), and bcl-2, and enhancing their expression [ 17, 60, 61].
