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In the protein view the amino-acid changes are listed and the arrows indicate the location of the mutations (Bromo, bromodomain; CH, cysteine histidine rich; HAT, histone acetyl transferase domain; KIX, CREB binding; Q, polyglutamine stretch).
We used a ts13 cell line that has a TAF1 missense mutation [25] in its potential HAT (histone acetyltransferase) region, and shows TAF1-defective phenotype without changing overall structure of TFIID at the non-permissive temperature [26].
HAT: histone acetyl transferase.
HAT, histone acetyl-transferase; EID, environmentally induced decoherence.
ncRNAs: noncoding RNAs; TLS: translocated in liposarcoma; EWS: Transcriptional factor Ewing's sarcoma; HAT: histone acetyltransferase; TERRA: telomeric repeat containing RNA.
Histone modifiers include several regulatory factors such as histone acetyltransferases (HAT), histone deacetylases (HDAC), lysine methyltransferases (KMT), and lysine demethylases (KDM).
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In two different HF models, 50 mg curcumin/kg/day ameliorated systolic function and prevented myocardial hypertrophy by inhibiting p300-HAT (histone acetyltransferases) [ 158].
It can interact with HATs (histone acetyl transferases) and HDACs (histone deacetylases) to directly activate or repress gene promoters.
Histone modifications are catalyzed by many enzymes such as histone acetyltransferases (HATs), histone deacetylases (HDACs), histone methyltransferases (HMTs), and histone demethylases (HDMs).
Epigenetic modifications are carried out by families of histone acetyl transferases (HATs), histone deacetylases (HDACs), histone methyl transferases (HMTs) and histone demethylases (HDMs).
They serve as scaffolds for chromatin binding of HATs, histone deacetylases, and components of the SWI/SNF and Mediator complexes.
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