The study of construction behaviour and animal architecture has yielded significant insights into many areas of animal behaviour including decision making, optimal foraging and behavioural plasticity.
The systems approach of integrating biology, chemistry, and geology has yielded significant insights into the metabolism of two environments in the Soudan Mine.
Congenital inability to feel pain is very rare but the identification of causative genes has yielded significant insights into pain pathways and also novel targets for pain treatment.
The model system C. elegans has yielded significant insights into the overall physiology of development, stress and aging, but it has been more challenging to understand the tissue-level nuances of autophagy's role in these processes.
Historically, field observations have yielded significant insight into the environmental and biotic controls on phytoplankton standing stock, community composition and rates of primary production.
In order to study breast cancer, many investigators have used human derived cell lines that have yielded significant insight into the biology of breast cancer; yet these models remain an artificial in vitro system that may not reflect the in vivo biology.
Recent metagenomic studies of soils and biomass composts [ 6, 9, 16] have yielded significant insights into uncultivated microbial communities; these studies, however, have investigated only single or a few sampling time points, probably due to the considerable cost and labor-intensity of analyzing the metagenomic data.
Since its inception to measure the adhesion of cells to a transparent substratum, [ 1– 3], interference reflection microscopy (IRM) and reflection interference contrast microscopy (RICM) have yielded significant insights about the location and size of adhesion complexes and "focal contacts" (a name coined from an early application [ 4]).
Although the separate application of either model has yielded significant biological insights [3], [7], [12], [13], [19], [20], [21], a systematic assessment of these models, especially their agreement with each other has yet to be reported.
