This suggests that TRiC must have unique specificity and properties required for maintaining protein homeostasis in the eukaryotic system.
Group 1 CD1 molecules present lipids to a clonally diverse T-cell population in which the precursors have unique specificity for a single antigen (Barral & Brenner, 2007).
Lectins have long been used for purification and detection of glycans in many studies [ 70]; many lectins have overlapping affinity while some others have unique specificity, allowing for the efficient detection of differential expression of glycan structure.
This type of conservation is absent in the HMM since SH2 domains have unique specificity-determining binding site geometries.
It is thus possible that many of the uncharacterized peptidases will prove to have unique specificities and be equally useful, or at least physiologically interesting.
Prototypic Cluster A mAbs A32 and C11 bind to similar epitopes on gp120 but only weakly cross-compete with each other, suggesting they have unique specificities (Guan et al., 2013).
The top motif identified for each data set shows that each FruM isoform has unique sequence specificity.
Despite the general low affinity of Siglecs towards the sialylated structures, it appears that each Siglec has unique sialoglycan specificity profile with regard to the type of sialic acid, its linkage and the composition of underlying glycan structure.
We have added the following text to the Introduction: "CD33rSiglecs in humans are numbered (e.g., Siglecs-3, -5, -6, -7, -8, -9, -10, −11, -XII, −14 and −16), while murine CD33rSiglecs it appears that each Siglec has unique sialoglycan specificity profile with regard to the type of sialic acid, its linkage and the composition of underlying glycan structure".
Nonetheless, in most situations, this assumption could be misleading, as it is known that each CS has unique target specificities [ 65].
