SN30000 is an analogue of TPZ that has undergone extensive optimization of its diffusion and metabolism characteristics [46].
The entire length of the cDNA, Opt-VP1, which has undergone codon optimization of the N-terminus of the CAV VP1 capsid protein, was ligated into pGEX-4T-1 to give pVP1-opt; this was then used as described in a previous study [ 15].
The concept, consisting of tungsten armour slabs fixed on a tungsten-laminate tube inside which a jet distribution cartridge is placed, has undergone an extensive optimization process.
Today, the search engine is highly recognizable and easy to use, but since its inception, Google has undergone constant revision, optimization, and reconfiguration to deliver more accurate and relevant search results for users.
As such, this class of probes has undergone far less optimization in terms of tuning photophysical and Zn2+-binding properties.
This finding implies that the metal ligands in arginase enzymes may have undergone evolutionary optimization selecting for the optimal configuration that results in a maximal catalytic rate.
Green fluorescent protein (GFP) has undergone a long history of optimization to become one of the most popular proteins in all of cell biology.
In recognition of the expectation that 100% accuracy is a requirement, even under suboptimal conditions, the assays developed for the targets in this report have undergone extensive optimization to maximize accuracy even under less than optimal conditions.
The physical components, a library of capture antibodies, and the secondary reagents of the Q-Plex™ system have undergone extensive optimization for consistent implementation [ 18, 19].
The sgRNA of SpCas9 has undergone extensive sequence, length, and chemical optimizations to enhance gene editing activity10,13,16,32,33,34. In contrast Cpf1 crRNA engineering remains to be intensively explored, although a few studies have demonstrated that modifications at the 3′ end can improve Cpf1 activity18,31.
Her voice has undergone changes.
