For example, the mapping of phosphorylation sites and analyses of phosphorylation site mutants have tremendously contributed to our knowledge of different cellular processes.
The technique of photoelectron spectroscopy has contributed tremendously to our knowledge on the properties of semiconductor interfaces, in aspects such as the electronic structure at the interface, relating to band bending and the evolution of transport barriers such as the Schottky barrier and the heterojunction band offset.
Science has contributed tremendously to the progress in medicine but also to other aspects of society over the last 100 years or so, and to say that the world as it once was is a place we would want to go back to may be true for people in very privileged positions, but certainly not for most of us," says geneticist Martin Bobrow of the University of Cambridge.
In this context, Dr. Woodcock encouraged the Office of Clinical Pharmacology (OCP) to publish a PBPK Guidance, and stated that the modeling work performed thus far at CDER has contributed tremendously to overall drug development, in terms of safety and efficacy, which ultimately result in patient benefits.
X-ray crystal structures of these viral enzymes as well as in-depth understanding of the molecular basis of their activities have contributed tremendously to the development of antiviral compounds, currently approved or in advanced clinical trials for hepatitis C treatment.
