"Faith," he said, "has to be internalized with a relationship with God, and outside circumstances such as an attack on the World Trade Center may move us to action, but it will not necessarily change us on the inside.
So multiplication is a double terror: not only is it remote from our intuitive sense of number; it has to be internalized in a form that clashes with the evolved organization of our memory.
This crucial lesson still has yet to be internalized by many international donors, many of whom continue to favor interventions based on the distribution of simple commodities or health promotion by untrained volunteers alone, eschewing more substantial health system interventions because they seem complicated and expensive [ 7].
Consistent with these findings, the GPI-AP PrPC has been shown to be internalized by either clathrin-dependent [38] [41], or raft-mediated pathways [42], depending upon the cell types and the different techniques utilized.
Since PrPC has been shown to be internalized both via a raft-dependent or a clathrin-dependent pathway [38] [40], [56] depending on the cell lines and the experimental methods utilized, we decided to dissect the endocytic pathway of PrPC by identifying the specific molecular factors involved in its uptake.
Moreover, the IL-6/IL-6RA complex has been shown to be internalized and degraded, therefore production of IL-6 receptor would be essential to sustain IL-6 signaling [ 33].
Annexin A5 has been shown to be internalized into the PS expressing cell as a consequence of its property to form a 2-dimensional lattice on the cell surface [ 44].
Although there has been no experimental evidence for CLV1 internalization, other receptors such as FSL2 and BRI have been shown to be internalized [ 29].
Certain GPCRs, such as the M1 receptor and the glucagon peptide 1 receptor, are internalized and have been shown to be internalized via this pathway [36], [37].
In CPPsite, CPPs have been found to be internalized into more than 80 types of cell lines.
In particular, RAGE-Aβ complexes have been shown to be internalized and co-localize with the lysosomal pathway in astrocytes in AD brains [ 56].
