Several international organizations have therefore recognized the need for standardization of the immunocytochemical assay and for its evaluation in prospective studies [ 13- 15].
TLR4 has therefore been recognized as an important pharmacological target.
It is frequently reported to be overexpressed in various cancers [ 30] and has, therefore, been recognized as an oncogene.
It has therefore been recognized that the interaction of CD4+ T lymphoblasts with the healthy brain barriers represents the critical step in the initiation of the disease.
Interaction of auto-aggressive immune cells with the blood brain barrier endothelium has therefore been recognized as a major pathophysiological hallmark of EAE and multiple sclerosis.
For example, Plk1 phosphorylates several checkpoint factors, leading to their deactivation, and has been therefore recognized as a key player of checkpoint recovery [ 3, 4].
Sugar metabolizing enzymes have, therefore, been recognized as key gatekeepers of carbon allocation and partitioning pathways in plants [ 2, 3].
It has, therefore, more recently been formally recognized as a true CEH criterion (by the CHISG classification committee; TAF & OS: two of the three original members, and by: FA, previous chairman of the group).
The piRNA/22G RNA pathway has therefore been proposed as a sophisticated mechanism for recognizing and silencing foreign sequences.
The ability to recognize, prevent and manage functional loss has therefore become an indispensable competency in acute care settings.
siRNAs have, therefore, been widely recognized as novel potential therapeutics.
