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"The study shows it having a small to moderate average effect for patients, meaning there will be some people who experience little or no effect and other people for whom it has substantial benefit.
Appreciations concerning spa therapy differ, some patients considering that it has substantial benefit and others considering it as a simple distraction.
As it happens, several randomized controlled trials of carotid endarterectomy that ensued showed that it has substantial benefit for symptomatic patients with severe narrowing of the carotid artery, but not for those who had mild narrowing or who had no symptoms associated with the narrowing [ 9].
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In addition, new evidence suggests that out-migration of highly skilled individuals has substantial benefits, mainly for "the migrants themselves, who benefit through massive gains in income and through greater human capital" (Gibson and McKenzie 2012: 371).
But the truth is that having a younger boss often has substantial benefits.
Our study has shown that even in an area with up to six months of intense transmission, monthly IPTc with AS+AQ has substantial benefits in reducing the incidence of malaria and anaemia.
This is fully justified for breast, ovarian and possibly stage III IVa cervical cancer, where the available evidence shows that chemotherapy has substantial benefits [11], [12], [16], [17].
However, we believe that this simplicity has substantial benefits.
As breastfeeding has substantial benefits for both mother and infant [ 31], these results are concerning.
The shRNA-based transgene strategy has substantial benefits over vaccination by offering potential sub-serotype protection when using multiple-shRNA expression systems targeting different viruses (Cong et al., 2010).
Tamoxifen is currently used to treat all stages of oestrogen receptor-positive breast cancer and, in the adjuvant setting, has substantial benefits in terms of disease-free and overall survival (Early Breast Cancer Trialists Collaborative Groupp, 1992).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com