Presented results importantly demonstrate that chaetocin has substantial activity in solid tumour models and not just in multiple myeloma as we had previously reported.
On one hand, Miller said he would be concerned if Kensington continues to have substantial activity in California despite the closure order.
New regimens that have substantial activity in phase II studies and are not associated with cumulative dose-related toxicities have recently been developed.
Herein, we report that rationally designed zolpidem anagrams, as well as additional analogues, have substantial activity against replicating, multi- and extensively drug-resistant Mtb clinical strains.
These results are compatible with findings from a clinical trial in which sunitinib had substantial activity against GISTs with secondary KIT exon 13 mutations [ 31].
In both dogs and people, standard chemotherapy agents do not have substantial activity in either the primary disease or in the setting of metastasis [ 1, 3- 7, 43].
The existence of APAP-G suggests that UGT isoform other than UGT1A1 and UGT1A9 (defined as having almost negligible activities in the neonates), namely UGT2B15, should have substantial activity at birth.
A recent pilot trial found that continuous, low-dose GM-CSF had substantial activity (objective response rate 37%) in heavily pretreated patients with either metastatic breast cancer or female genital tract cancer (Kurbacher et al, 2005).
Irinotecan, as a single-agent, had substantial activity in vitro in four neuroblastoma cell lines, achieving 1.1 2.8-log 1.1 2.8-logy at 20 ng ml−1 (acytotoxicity patients, Vassal et al, 2003), ang in our xenograft ml−1ls.
