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It is of note, however, that since the original identification of PINK1 being up-regulated by exogenous PTEN, only one study has subsequently observed this effect (Siddall et al, 2008) and the link between PINK1 and PTEN in PD has yet to be confirmed.
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Although we have subsequently observed three BARD1 mutation carriers in our cohort since the time of data collection for this study, the mutation frequency remains low.
This regulatory system has subsequently been observed to aid Mtb survival and growth under anoxic conditions [17], [18], [19].
A rapid demographic and spatial expansion to a large part of Europe has subsequently been observed [ 47, 48].
Na+ and/or H+/OH− transport mediated by SLC4A11 has subsequently been observed in other mammalian cell lines [ 20, 31] and in cultured bovine corneal endothelial cells [ 17].
However, this same variant has subsequently been observed in an additional individual with mental retardation [ 64], but not in 320 controls with similar ethnic background.
A stereotyped environmental stress response to a wide range of stressors and toxicants was first demonstrated in yeast (Gasch et al. 2000) and has subsequently been observed in a variety of mammalian cell models (Heinloth et al. 2003; Morgan et al. 2002; Murray et al. 2004; Park et al. 2002; Sesto et al. 2002; Weigel et al. 2002).
The phenomenon has subsequently also been observed at longer wavelengths and, ultimately, led to the realization of surface-enhanced infrared absorption spectroscopy (SEIRAS) [ 3].
Resistance switching effect was first reported by Hickmott in 1962 [32] and had subsequently been observed by many researchers over the years [9 36].
In Dresden/Saxony, the authors identified the first case of a USA300 infection in 2005 [29], but only sporadic isolates have subsequently been observed (including three among 304 genotyped MRSA isolates from patients of the University Hospital Dresden, 2007 to 2009, unpublished observation by the authors).
Abnormal levels of these lipids in the blood have subsequently been observed in diabetics with or susceptible to cardiovascular complications and microangiopathy [ 2].
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