It represents a chemical prototype from which newer generation analogues have since been generated that lack some potentially deleterious effects of probucol (Stocker, 2009), including lowering HDL cholesterol and prolonging cardiac repolarization (QTc interval).
SCNT has since been used to generate a wide variety of mammalian clones, from different types of adult cells; its success in producing clones of primates, however, has been notably limited.
It was first described for yeast, and has since been applied to generate maps of bacteria, eukaryotic parasites, plants and vertebrates [ 1].
Apoptosis was first discovered over forty years ago and has since been studied in intricate detail, generating a complex web of interactions that define this process (Kerr et al., 1972).
The Gateway entry clones have since been used to generate over 5,000 different expression constructs that have been successfully exploited in functional profiling applications [ 13, 14, 23, 24].
In addition, we have since been able to generate in-vivo teratoma formation in mice testes with the chicken iPS-like cells for a longer survival period than the embryos we tested.
Other tag-based methodologies, especially those for gene identification and establishing transcriptional start points, have since been developed that generate longer tags from the 3' or 5' ends of transcripts, or both (reviewed in [ 12]).
A number of promising candidates have since been identified in libraries generated this way (Horswill et al. 2004; Tavassoli and Benkovic 2005; Tavassoli et al. 2008).
The videos have since been thoroughly debunked, but they generated enough anger among abortion opponents that Congress established a special committee to investigate the video's claims.
The model, and the theory which it generated, have since been used by other researchers including, for example, a team seeking to embed effective depression care within Australian primary care [ 18].
