At these length scales, fabrication of the nanoimprint mold is a significant challenge, as standard fabrication processes will have significant defects at the required density.
IR8 provided a huge yield advantage when combined with improved agronomic management practices, but it had significant defects, such as poor cooking quality, long-duration, and susceptibility to diseases and insects.
It's impossible to determine how many other residential properties have significant defects like this but it would be a mistake to assume Shedd is the last homebuyer who's going to experience this kind of disaster.
In NH4Ac chemotaxis assays odr-1 mutants have significant defects only in odorant assays (Fig. 2B).
Dopamine deficient cat-2, octopamine deficient tbh-1 and tyramine deficient tdc-1 mutants did not have significant defects.
However, in vitro-cultured RASSF9−/− keratinocytes were found to have significant defects or delays in terminal differentiation.
Consistently, swi3-E31, swi3-NBT7 and E40 had impaired Cds1 activity (Figure 6A) and had significant defects in resumption of replication after HU treatment (Figure 5B).
mDUX (n = 120) embryos were observed to develop normally through gastrulation one day post-injection but had significant defects in tail development at three days post-injection compared to GFP controls (n = 120).
Likewise, Fmr1/Fxr2 DKO mice have significant defects in basal synaptic transmission which are not detectable in either single null (57).
