Sentence examples for has significant activity from inspiring English sources

The T172D mutant cannot be phosphorylated and activated by upstream kinases but has significant activity and retains allosteric activation by AMP (Stein et al., 2000).

Compound 22 has significant activity in inhibiting both IgE- and IgG-mediated activation of Fc receptor (FcR) in mast cells and basophils, and in addition inhibits Syk kinase-dependent activity of FcR-mediated activation of monocytes, macrophages, neutrophils, and B cell receptor (BCR -mediated activation of BCR -mediated.

A 300-base pair fragment of the heavy chain enhancer was inactive in F9 EC cells, unlike in other nonlymphoid cells where it has significant activity.

Background and purpose: Fludarabine, 9-β-d-arabinofuranosyl-2-fluoroadenine, is an adenine nucleoside analogue that has significant activity in hematological malignancies and has shown promising activity in combination with radiation in preclinical solid tumor models.

The Arg175Lys mutant has significant activity and near-normal bicarbonate Ka (Table 1).

Bevacizumab is a humanised monoclonal antibody directed against VEGF, which has significant activity against several solid tumours.

While benzimidazoles are active against many species of microsporidia, these drugs do not have significant activity against Enterocytozoon bieneusi.

A large number of essential oils is reported to have significant activity against Candida albicans.

A sage (Salvia officinalis) oil from Montenegro with the main compounds α-thujone (29.5%), camphor (22.5%) and 1,8-cineole (12.2%) had significant activity against C. albicans[34].

Results of pharmacophore modeling showed that compounds 1, 8, 9 and 10 have significant activity against human anticancer target aromatase [38].

Streptomyces kanasenisi ZX01 was found to produce a novel glycoprotein GP-1 previously, which was secreted into medium and had significant activity against tobacco mosaic virus.