Sentence examples similar to has significant activities from inspiring English sources

The T172D mutant cannot be phosphorylated and activated by upstream kinases but has significant activity and retains allosteric activation by AMP (Stein et al., 2000).

We conclude that topotecan has significant activity in MDS and CMML, with acceptable side effects.

One site requires both repeat domains 3 and 4. The other site involves both repeat domains 2 and 3, although domain 2 has significant activity alone.

A 300-base pair fragment of the heavy chain enhancer was inactive in F9 EC cells, unlike in other nonlymphoid cells where it has significant activity.

CONCLUSION: Weekly low-dose carboplatin and paclitaxel has significant activity in both platinum-sensitive and platinum-resistant recurrent ovarian cancer with acceptable toxicity that is easily managed by dose adjustment.

The Arg175Lys mutant has significant activity and near-normal bicarbonate Ka (Table 1).

To summarize, in previously untreated CLL, lenalidomide has significant activity but clinical development has been impaired due to significant toxicity.

Bevacizumab is a humanised monoclonal antibody directed against VEGF, which has significant activity against several solid tumours.

Oxaliplatin has significant activity against some cisplatin-resistant tumors and a favorable safety profile over cisplatin[ 24].

6, F1) have significant activity on the substrate p-nitrophenyl α- L-arabinofuranoside, one enzyme (A3) has significant activity on the substrate p-nitrophenyl β- D-glucopyranoside, and one enzyme (E2) has significant activity on the substrate p-nitrophenyl β- D-xylopyranoside.

The schedule of IFN-α, IL-2 and PVI 5FU has significant activity in advanced renal cell cancer with manageable toxicity.