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Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, has shown protective effects against ischemic insult in various tissues.
Humanin (HN) is an endogenous mitochondrial-derived cytoprotective peptide that has shown protective effects against atherosclerosis and is expressed in human vessels.
Reportedly, adenoviral delivery of NAIP, HIAP1 and HIAP2 has shown protective effects on ischemic damage [7] and sciatic axotomy [8].
Conversely, the ϵ2 allele of the APOE gene has shown protective effects against AD [ 13].
Ketamine is an anesthetic with anti-inflammatory properties, which has shown protective effects on IRI in various organs [ 29, 30].
Quercetin has shown protective effects against amyloid-beta pathology and may have a therapeutic role for tau aggregation.
Similar(52)
In general, single dose antioxidant interventions have shown protective effects with respect to WBC DNA oxidation.
A number of studies, although not all, have shown protective effects of low dose CO exposure in various animal models of tissue inflammation and dysfunction [21].
MMP-2-neutralizing antibodies have shown protective effects in hearts exposed to ischemia-reperfusion injury (79).
Poly-hydroxylated 1,4-naphthoquinones occur as sea urchin pigments and have shown protective effects [ 1753].
Compounds that activate Nrf2 have shown protective effects in animal models of PD, whereas mice lacking Nrf2 are susceptible to DA neuron degeneration in response to toxic exposures.
More suggestions(15)
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has shown variable effects
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